Former first lady Barbara Bush is in "failing health" and won't seek additional medical treatment, a Bush family spokesman said.
"Following a recent series of hospitalizations, and after consulting her family and doctors, Mrs. Bush, now age 92, has decided not to seek additional medical treatment and will instead focus on comfort care," spokesman Jim McGrath said Sunday in a news release.
McGrath did not elaborate as to the nature of Bush's health problems. She has been treated for decades for Graves' disease, which is a thyroid condition, had heart surgery in 2009 for a severe narrowing of her main heart valve and was hospitalized a year before that for surgery on a perforated ulcer.
After Sunday's news, well wishes poured in for Bush from politicans, lawmakers, newsmakers and ordinary citizens.
"She is surrounded by a family she adores, and appreciates the many kind messages and especially the prayers she is receiving," McGrath said.
Bush, who is at home in Houston, is one of only two first ladies who was also the mother of a president. The other was Abigail Adams, wife of John Adams, the nation's second president, and mother of John Quincy Adams, the sixth president.
Bush married George H.W. Bush on Jan. 6, 1945. They had six children and have been married longer than any presidential couple in American history.
Bush is known for her white hair and her triple-strand fake pearl necklace.
Her brown hair began to gray in the 1950s, while her 3-year-old daughter Pauline, known to her family as Robin, underwent treatment for leukemia and eventually died in October 1953. She later said dyed hair didn't look good on her and credited the color to the public's perception of her as "everybody's grandmother."
Her pearls sparked a national fashion trend when she wore them to her husband's inauguration in 1989. The pearls became synonymous with Bush, who later said she selected them to hide the wrinkles in her neck. The candid admission only bolstered her common sense and down-to-earth public image.